Study objective: To characterize and compare sex hormone concentrations, and uterine and ovarian volumes in adolescent girls born small for gestational age SGA who had experienced catch-up growth and girls born at a size appropriate for gestational age AGA , and to investigate the association between these parameters and glucose metabolism, perinatal factors, and early growth.
Design: A prospective, longitudinal, observational study from birth until adolescence. Setting: Mean age at final assessment was Interventions and main outcome measures: Sex hormone concentrations gonadotropins, estradiol, testosterone, and sex hormone binding globulin were analyzed, and the oral glucose tolerance test conducted. Uterine and ovarian sizes were assessed using pelvic ultrasound. Birth weight and early infancy height velocity explained Conclusion: SGA-born girls who experienced catch-up growth remain at risk of biochemical hyperandrogenism in adolescence, and have reduced uterine and ovarian volumes, which might influence future reproductive function.
Ovarian size and androgen levels in adolescence might be influenced by early growth and subcutaneous fat deposition. Published by Elsevier Inc. All rights reserved. Abstract Study objective: To characterize and compare sex hormone concentrations, and uterine and ovarian volumes in adolescent girls born small for gestational age SGA who had experienced catch-up growth and girls born at a size appropriate for gestational age AGA , and to investigate the association between these parameters and glucose metabolism, perinatal factors, and early growth.
Publication types Observational Study.
