Official websites use. Share sensitive information only on official, secure websites. Osteoporosis OP is a major disease that affects million people worldwide. Fatty acid metabolism plays an important role in bone health and plays an important role in bone quality and remodeling.
Increased bone marrow fat quantity has been shown to be associated with a decrease in bone mineral density BMD , which is used to predict fracture risk. Overall, the results of this study suggest that assessment of adipose tissue via 3T CSE-MRI provides insight into the pathophysiology fracture risk by showing differences in the bone marrow and muscle fat content in subjects with similarly osteoporotic BMD as assessed by DXA, but with varying degrees of fracture risk as assessed by FRAX.
Osteoporosis OP is a disease of fragile bones which increases fracture risk Fx in the aging population and represents an important public health problem. Fx risk assessment is commonly made using dual-energy x-ray absorptiometry DXA , which allows assessment of the mineralized component of bone both trabecular and cortical via estimation of areal bone mineral density BMD.
This measurement allows the computation of a T-Score, which has been used as a means to define OP status Hillier et al. However, DXA, as a 2-D planar technique, does not assess all the changes in bone tissue that can occur in the aging process and does not completely capture fracture risk.
The T-score threshold used to define fracture risk and initiation of treatment is not optimal when applied to patients who are premenopausal, obese, diabetic, suffering from cancer, or corticosteroid therapy Elde and Madsen, ; Leslie et al.
