The aim of the study was to estimate the effect of the accumulation of major life events MLE in childhood and adulthood, in both the private and working domains, on risk of type 2 diabetes mellitus T2DM. Furthermore, we aimed to test the possible interaction between childhood and adult MLE and to investigate modification of these associations by educational attainment.
The study was based on 4, participants from the Copenhagen City Heart Study free of diabetes at baseline and followed for 10 years. MLE were categorized as 0, 1, 2, 3 or more events. Multivariate logistic regression models adjusted for age, sex, education and family history of diabetes were used to estimate the association between MLE and T2DM.
There was no evidence that experiencing MLE in both childhood and adult life was more strongly associated with T2DM than experiencing events at only one time point. Findings from this study suggest that the accumulation of MLE in childhood, private adult life and work life, respectively, are risk factors for developing T2DM.
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To request use of the data, contact Merete Appelyard at merete. Any interested researcher will be able to obtain a dataset pending ethical approval. Funding: This work was supported by the Center for Healthy Aging, University of Copenhagen grant number: The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Competing interests: The authors have declared that no competing interests exist.
