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Objective: Type 2 diabetes diabetes is characterized by accelerated cognitive decline and higher dementia risk. Controversy exists regarding the impact of metformin, which is associated with both increased and decreased dementia rates. The objective of this study was to determine the association of metformin use with incident dementia and cognitive decline over 6 years in participants with diabetes compared with those not receiving metformin and those without diabetes.
Exclusion criteria were dementia, major neurological or psychiatric disease, or progressive malignancy. These were used to determine the measure of global cognition. Incident dementia was ascertained by a multidisciplinary panel. Conclusions: Older people with diabetes receiving metformin have slower cognitive decline and lower dementia risk. Large randomized studies in people with and without diabetes will determine whether these associations can be attributed to metformin.
Abstract Objective: Type 2 diabetes diabetes is characterized by accelerated cognitive decline and higher dementia risk. Substances Hypoglycemic Agents Metformin.