Nigella sativa NS Ranunculaceae used as a protective and therapeutic traditional medicine. This study evaluates the effect of NS on inflammation-induced myocardial fibrosis, serum and tissue inflammatory markers, and oxidative stress status in male rats. The duration of LPS administration was two weeks.
At the end of the experiment, blood samples were taken and ventricles were homogenized and stained for histological evaluation.
Serum nitrite levels were lower in LPS group than the control group Histopathological studies showed higher inflammatory cell infiltrates, cardiac fibrosis, and collagen deposition in LPS group, which were reduced by the administration of NS.
Plants are significant sources of new medications, and interest in medicinal plants has expanded because of the effectiveness of new plant-derived drugs. Moreover, as a result of worries about the side effects of conventional medicine, the utilization of natural products as a replacement for synthetic medications has risen considerably in the recent decades. The wide use of herbal medications has encouraged researchers to examine their amazing impacts on health, and an expansive number of therapeutic plants and their active extracted ingredients are broadly considered for their potentials to protect cells from injuries.
Among the promising medicinal plants is Nigella sativa NS Ranunculaceae 1 , 2. NS is used as a protective and therapeutic traditional medicine in the Middle East and a number of Asian countries 3. It is rich in different phytochemicals whose benefits have been indicated in both in vivo and in vitro studies.
